Determining whether a research risk meets or exceeds a regulatory standard of risk acceptability is difficult. Recently a framework called the systematic evaluation of research risks (SERR) has been proposed as a method of comparing research risks with predetermined standards of acceptability. SERR purports to offer a systematic and largely determinate (definite) way to compare risks and say whether a specific research risk falls below or above an acknowledged standard of acceptable risk. Here the authors review some philosophical problems with (...) this framework, which they take to be representative of determinate approaches to risk comparison, and conclude that it should not be used in a stand-alone or determinate fashion. Instead, the authors suggest that a deliberative approach may be a more viable candidate for future development. Such an approach could be informed by methods such as SERR without being rigidly bound to them. (shrink)

BackgroundThe return of genetics and genomics research results has been a subject of ongoing global debate. Such feedback is ethically desirable to update participants on research findings particularly those deemed clinically significant. Although there is limited literature, debate continues in African on what constitutes appropriate practice regarding the return of results for genetics and genomics research. This study explored perspectives and ethical considerations of Ugandan genomics researchers regarding the return of genetics and genomics research results.MethodsThis was a qualitative study that (...) employed in-depth interviews. Thirty participants were purposively selected based on their expertise as genomics researchers in Uganda. Data were analysed through content analysis along the main themes of the study using a comprehensive thematic matrix, to identify common patterns arising from the narratives. NVivo software 12 was used to support data analysis.ResultsThe return of genetics and genomics research results was generally acceptable to researchers, and some indicated that they had previously returned individual or aggregate results to participants and communities. The main reasons cited for sharing research results with participants included their clinical utility, actionability and overall benefit to society. Ethical considerations for appropriate return of results included a need for effective community engagement, genetic counselling prior to disclosure of the results, adequate informed consent, and proper assessment of the implications of, or consequences of returning of results. However, the approaches to return of results were perceived as unstandardized due to the lack of appropriate regulatory frameworks.ConclusionsThe return of genetic and genomic research results is generally acceptable to researchers despite the lack of appropriate regulatory frameworks. Ethical considerations for return of genetics and genomics research results are highly divergent, hence the need for national ethical guidelines to appropriately regulate the practice. (shrink)

NATURES AND FUTURES FOR POLITICAL THEORY John S. Nelson What are the problematics, histories, forms, aims, conditions, methods, and topics proper to political theory? Plainly, these change from one context to another; and yet they may ...

Following the above scheme of demonstration, the first part of the present discussion will be devoted to a refutation of the arguments that support scepticism on the point under discussion. The second part of the discussion will then be devoted to proving that we do know remote existences.

"The ontology of the 1899 paper may then be summed up as follows," says Mr. Hochberg. "There are two kinds of entities, existents and non-existents.... All existent entities are made up ultimately of simple concepts which are non-existent. Also, all other non-existent entities are likewise reducible to simple concepts. The category of existent entities includes simple objects, like yellow1, and complex objects, like Paul, as well as existential propositions. In addition to simple concepts, the category of nonexistent entities includes non-existential (...) propositions, and complex concepts like the concept of Paul." By "simple object," Hochberg means any complex of concepts in which a single adjectival concept, like red or yellow, is tied together by some ontological relation, R, involving containment, with the concepts existence and now. Any such composite, denoted by the words, e.g., R2, R2, etc. or by the words "red1," "yellow1," etc., is a particular, since it has temporal existence. Every complex composed of simple objects and only such complexes are likewise particulars, in contrast to simple or complex concepts, which are universals. Thus, as Hochberg interprets him, Moore in "The Nature of Judgment" denies existence to universals, while maintaining that particulars, and only particulars, exist. (shrink)

U.S. federal research funding is generally justified by promises of public benefits, but the specific natures and distribution of such benefits often remain vague and ambiguous. Furthermore, the metrics by which outcomes are reported often do not necessarily or strongly imply the achievement of public benefits. These ambiguities and discontinuities make it difficult to assess the public outcomes of federal research programs. This study maps the terms in which the purposes and the outcomes of Advanced Research Projects Agency-Energy -a relatively (...) young and innovatively structured federal research agency-have been discussed and reported. I find that ARPA-E’s creation and funding have been justified with reference to a broad repertoire of economic, environmental, and national security values, but that the agency has been evaluated only through intermediate scientific and economic metrics and study of internal organizational structure. I suggest that these means of assessment elide ARPA-E’s lack of the financial scale, long time horizon, built-in customer, and radical vision which have been historically important to high-impact federal innovation, and I recommend the tracking of metrics more directly related to ARPA-E’s public value purposes as the agency grows older. This discussion illustrates the inadequacy of currently widespread metrics and conventional wisdom for the design and assessment of societally relevant research. (shrink)

Let me first explain what I am not attacking in this paper. I am not attacking, for instance, the right of free speech or any of the other specific rights listed in the U.S. Constitution's Bill of Rights or the United Nations' Charter. I am, rather, attacking any specific right's being called a ‘human right’. I mean to show that any such designation is not only fraudulent but, in case anyone might want to say that there can be noble lies, (...) grossly wicked, amounting indeed to genocide. (shrink)

Pierre Trémaux’s 1865 ideas on speciation have been unjustly derided following his acceptance by Marx and rejection by Engels, and almost nobody has read his ideas in a charitable light. Here we offer an interpretation based on translating the term sol as “habitat”, in order to show that Trémaux proposed a theory of allopatric speciation before Wagner and a punctuated equilibrium theory before Gould and Eldredge, and translate the relevant discussion from the French. We believe he may have influenced Darwin’s (...) revision to the third edition of the Origin on rates of evolution, and suggest that Gould’s dismissal of Trémaux is motivated by concern that others might think punctuated equilibrium theory was tainted by a connection with Trémaux. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Missing Shade of Blue Re-viewed John 0. Nelson It is obviously important for Hume's purposes in the Treatise to maintain that simple ideas are always founded in precedent, resembling impressions;1 andhe explicitly, overandover, doesso, evensometimes being so carried away by this first principle ofhis science of man (T 7) or so careless as to say that not just all simple ideas but all ideas are founded (...) in precedent, resembling impressions. At the same time, as often noted, Hume explicitly maintains that it is possible for there to be a simple idea having no precedent, corresponding impression. He argues: There is however one contradictory phaenomenon, which may prove, that 'tis not absolutely impossible for ideas to go before their correspondent impressions... Suppose... a person to have enjoyed his sight for thirty years, and to have become perfectly well acquainted with colours of all kinds, excepting one particular shade of blue... Let all the different shades of that colour, except that single one, beplac'd before him... Now Iask, whether 'tis possible for him, from his own imagination, to supply this deficiency, and raise up to himselfthe idea ofthat particular shade, tho' it had never been conveyed to him by his senses? I believe there arefew but will be ofopinion that he can; and this may serve as a proof, that the simple ideas are not always derived from the correspondent impressions. (T 5) Nowjust prior to this concession (as Cummins calls it ), Hume has said that the full examination ofthis question [the causal relationship between ideas and impression] is the subject of the present treatise; and therefore we shall here content ourselves with establishing one general proposition, That all our simple ideas in their first appearance are deriv'd from simple impressions, which are correspondent to them, and which they exactly represent. (T 4) Volume XV Number 2 353 JOHN O. NELSON And just after the same concession, that a simple idea may be raised up which does not have a prior, correspondent impression, Hume says that it still remains true, that all our simple ideas proceed either mediately or immediately, from their correspondent impressions (T 7). Thus we have Hume explicitly asserting, it seems, both that all simple ideas have precedent correspondent impressions and that they do not. But this, on the face ofit, is an arrant contradiction! Can Hume have Homerically nodded? We have been quoting from the Treatise, but Hume makes the very same contradictory-seeming claims in the Enquiryl A thinker of Hume's acumen might nod for a page or two's quarter hour but not for all of nine years! Moreover, in both places Hume refers to the phenomenon of the impression-less idea ofblue as a contradictory phenomenon, indicating clearly enough that he was himself aware of there seeming to be an inconsistency here in his contentions. What can possibly be going on? Is Hume deliberately being paradoxical? Perhaps trying, for sensation's sake, to shock the reader and so increase sales of his work, as some commentators in the past might have wished to say? But this would be at the expense ofhis own contentions and principles and not the reader's, and not even Hume's bitterest foes and most malicious critics — so far as I know — have ever proposed that Hume would, figuratively speaking, like Oedipus, gouge out his own eyes, even in order to increase sales of the Treatise, nor does it make the slightest sense to think he would. The mystery deepens when we remember that Hume has said, in defining the program of the Treatise, that his intention is to establish the one general proposition that all our simple ideas in their first appearance are deriv'd from simple impressions, which are correspondentto them (T4). What astrange way, we want to exclaim, to show that all our simple ideas are derived from correspondent simple impressions by almost immediately afterwards arguing that it is possible to have an idea that has had no correspondent, precedent impression! Such an egregious nonsequitur mightbe expected ofan absolutely incompetent beginner in philosophy, but we are speaking of David Hume, generally recognized as the profoundest and most acute of... (shrink)

In the United Nations' Universal Declaration of Human Rights a quite large number of things are said to be ‘human rights’ and though in that Declaration the term ‘inalienable’ is not used to describe the rights in question it has been so used by commentators—at least with respect to some of the rights enumerated. I shall forgo asking the prior question as to whether any such thing as a human right exists and ask simply whether any such thing as an (...) inalienable right exists. My intention will be to show that it does not. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Authorship of the Abstract Revisited John 0. Nelson More than a dozen years ago, in the pages of The Philosophical Quarterly,1 this writer contested Sraffa and Keynes' claim, advanced in the introduction to their edition ofthe Abstract? that it was Hume and not Adam Smith (as traditionally supposed) who was the author of that work. The traditional view, which might be called the Adam Smith authorship-theory, (...) was largely inspired by and seemed nailed shut by Hume's reference to a "Mr Smith" in a letter to Francis Hutcheson, datedMarch 4, 1740.3There appeared tobe goodreasonsforidentifying this "Mr Smith" with Adam Smith and then the latter with the undivulged author of the Abstract. It was known, for instance, that previous to March 4, 1740, Adam Smith had been a student of Hutcheson's and that Hutcheson was in the habit of setting his students the task of writing abstracts of newly published philosophical works.4 Since Hutcheson had originallylooked with favor on both the Treatise and its author,5 it had to seem more than likely that he had set his students the task ofwriting an abstract ofthe newly published Treatise ofHume. It was known, too, that Adam Smith was in possession of a copy ofthe Treatise soon after the date of H.6 Who, then, might be the "Mr Smith" adverted to in H's "My Bookseller has sent to Mr Smith a Copy of my Book, which I hope he has receive, as well as your Letter," except that same student of Hutcheson's, Adam Smith? What other Smith might have been known to Hutcheson, whom Hume could have wanted to refer to? No other Smith appeared to fit the bill. But why should Hume have wanted to refer in his correspondence with Hutcheson to an obscure, sixteen-year-old student ofHutcheson's, besides going to the trouble of having his bookseller send him a copy of the Treatise, unless that student had in some way made himselfnot only known to Hume but so highly regarded that Hume would want to favor him, presumably at his own expense, with a copy ofthe Treatise? The only tenable answer had to seem to be that this same student had composed such a perceptive and laudatory précis of the Treatise for Hutcheson that the latter had shown it to Hume and Hume, in the honest attempt to excite interest and sales of that languishing work, had seen to its publication as the Abstractl These are the reasonings Volume XVII Number 1 83 JOHN O. NELSON and considerations that inspired and seemed to confirm the Adam Smith authorship-theory.7 As can be perceived, these reasonings and considerations all revolve around the reference to a "Mr Smith"in H andthe identification of that Smith with Adam Smith. When, therefore, Sraffa and Keynes in the introduction to their edition oftheAbstract pointed out that there existed another Smith who might arguably be the Mr Smith referred toin H, namely, the DubUn publisher oftwo ofHutcheson's works, John Smith "at the Philosopher's Head on the Blind Quay," its major prop being seemingly knocked out from under it, the Adam Smith authorship-theory crashed—at least in the eyes of the general world—to the ground. And in thelatter's place, various ofits supporting reasons being given a lease on life, such as Hume's well-known endeavors and desires to excite interest in this first work of his, the Hume authorship-theory, so to speak, seated itself. In my previous venture into this subject, "Has the Authorship of An Abstract ofa Treatise ofHuman Nature Really Been Decided?"8 I tried, I believe with some success, to show that Sraffa and Keynes' arguments were not so unanswerable as they were generally taken to be and that, in fact, they presented various difficulties which the traditional theory avoided. But what then occasions this new excursion into these troubled waters? What more is to be said that I did not say in "Decided"? In "Decided" I presented various arguments and considerations that showed that it was unlikely either that Hume was the author of theAbstract or that the Mr Smith referred to in H... (shrink)

In his recent work, The Significance of Philosophical Scepticism, Barry Stroud proposes to carry out an in-depth critique of the attempt by philosophers to invalidate all knowledge of an external world on the basis of Descartes' dream argument. His more particular aims in this endeavour are to uncover significant features of any such scepticism and to disclose in the process fundamental aspects of ‘human knowledge’ itself. Thus, among other features of knowledge that his study discloses, he thinks, is, echoing Kant, (...) the idea ‘that a completely general distinction between everything we get through the senses, on the one hand, and what is true or not true of the external world, on the other, would cut us off forever from knowledge of the world around us.’ And a significant feature of Cartesian dream scepticism he believes to have uncovered is that its ‘effectiveness’ rests upon the philosopher's traditional assumption of an objectively existent world that is understandable ‘from a detached “external” viewpoint.’. (shrink)

There are, no doubt, a variety of reasons, good and bad, why anyone might want to treat a worker's labour, and most people, consciously or unconsciously do, as a commodity.

Russell said that physics drove him to a position not unlike that of Berkeley —by which he meant subjectivism or solipsism. ‘As regards metaphysics’, he tells us in hisAutobiography, ‘when, under the influence of Moore, I first threw off the belief in German idealism, I experienced the delight of believing that the sensible world is real. Bit by bit, chiefly under the influence of physics, this delight has faded, and I have been driven to a position not unlike that of (...) Berkeley, without his God and his Anglican complacency’. (shrink)

We must agree, I think, with Frank Ebersole that there is something preposterous in supposing that the God of religious belief, the God who handed down tablets to Moses on Mt. Sinai, etc., should be proven to exist by the ontological argument. Indeed, when we place the one, the ontological argument, by the side of the other, the God of religious belief, there seems hardly to be any connection between them. But if we agree to this perception of things, what (...) sense can we make of the ontological argument, for example, the “pull” that it sometimes exerts on us? (shrink)

Pre-analytically at least some of our inductions seem to be possessed of rational justification. This comment would apply, for instance, to my present induction, ‘If that climber high on the Flatirons falls he will be killed,’ not to mention such more momentous inductions as, ‘If a full-scale nuclear war breaks out there will be greater destruction than in World War II.’ Notoriously, however, a few Humean reflections seem to strip even the most plausible of our inductions of all possible rational (...) justification, leaving them mere bare psychological faits accomplis: in effect, section V of the Enquiry's ‘Sceptical Solution of these Doubts.’. (shrink)

In this essay I try, first, to show that Lockean passages in Book I can be given a Berkeleian interpretation. I take two passages that have, in particular, been cited as allowing only a Lockean interpretation and show how they can be more coherently construed as Berkeleian in their intended meaning. In the process of this demonstration I show that only a Berkeleian interpretation is tenable for Book I. Second, I defend the Berkeleian interpretation against several charges; for instance, a (...) charge of textual inconsistency. I do, however, acknowledge in the process that in the Enquiry and subsequently Hume abandons Berkeley for Locke. I then offer an explanation of why he did and lastly I try to show that though Hume is thereby committed to an inconsistency he provides a way for justifying his (and our) conversational commitment to that inconsistency. (shrink)

In response to a growing perception that America's youth lack the necessary values to grow and develop into adulthood in a socially healthy manner, character education has emerged as a rapidly growing proactive approach that serves to develop good character among young people. The authors examine several of the virtues thought to underlie good character from Character Counts!, a popular character education program, and emphasize the cultural complexities involved when promoting character education in a pluralistic society. 2012 APA, all rights (...) reserved). (shrink)

WHEN, CONTROVERSIALLY, IT IS MAINTAINED that Aristotle was a functionalist, what is meant by "functionalist" cannot have the sense of "teleological functionalist," for in that sense there can be no doubt that Aristotle was a functionalist. The sense of "functionalism" that is patently being exploited is that which appears in contemporary philosophies of mind with affinities to logical behaviorism but also with some important divergencies and which Paul Churchland describes as the view that "psychological states are functional states in the (...) sense that for any being to have a psychology is for it to instance or embody a certain functional organization among its sensory inputs, internal states, and motor outputs." It is in this philosophical-psychological sense that the title of this paper controversially asks, Was Aristotle a functionalist? and to which I mean to give a negative answer. Thus, unless otherwise stated, it shall henceforth be this sense of the term that occurs in what follows. In order, however, to avoid ambiguity I shall call such functionalism "mind-functionalism.". (shrink)

BackgroundGenetics and genomics research (GGR) is increasingly being conducted around the world; yet, researchers and research oversight entities in many countries have struggled with ethical challenges. A range of ethics and regulatory issues need to be addressed through comprehensive policy frameworks that integrate with local environments. While important efforts have been made to enhance understanding and awareness of ethical dimensions of GGR in Africa, including through the H3Africa initiative, there remains a need for in-depth policy review, at a country-level, to (...) inform and stimulate local policy development and revision on the continent.MethodsTo identify and characterize existing ethics-related guidelines and laws applicable to GGR across much of Africa, we conducted a scoping review of English language policy documents identified through databases, repositories, and web searches. Thirty-six documents were included and coded using a framework that contained a range of themes across five analytical categories: (1) respect, (2) beneficence, (3) justice, (4) independent oversight, and (5) bans and prohibitions. Data analysis software (NVivo 12) was used to organize, code, and tabulate information according to document characteristics and topics. Illustrative examples of policy requirements were selected for inclusion.ResultsDocuments that met inclusion criteria spanned 20 years; published between 1996 and 2018, with the majority (58%) published after 2009. About two-thirds were denoted as “guidelines,” and slightly more than half were non-exclusive to GGR. Very few (six) country-level documents identified were specific to GGR. Requirements related to the principle of “respect” appeared most often across all documents, relative to other principles and processes. The most commonly stated ban was on reproductive cloning. Other prohibitions applied to germline editing, undue inducements in research, sample use for commercial purposes, employee mandatory DNA testing, fetal sex selection, stem cell use, eugenics, and research without public health benefits.ConclusionsEnforceable policies that are indispensable to the ethical conduct and review of GGR are either deficient or missing in many African countries. Existing international, GGR-specific ethics guidelines can be used to inform GGR policy development at a country-level, in conjunction with insight from country specific ethics committees and other local stakeholders. (shrink)

(1988). Approaches, opportunities and priorities in the rhetoric of political inquiry: A critical synthesis. Social Epistemology: Vol. 2, No. 1, pp. 21-42.